PUBLICATIONS

As shown below, our work has been highlighted in a number of high impact peer reviewed journals and mainstream media publications (including the Washington Post, National Post and TCT MD.

Publications (Underline: Student Co-Authors)

2020 (3)

Rafatian, G., Kamkar, M., Parent, S., Michie, C., Risha, Y., Molgat, A.S.D., Seymour, R., Suuronen, E.J., Davis, D.R., Mybl2 rejuvenates heart explant-derived cells from aged donors after myocardial infarction. Aging Cell. doi.org/10.1111/acel.13174

Kanda, P., Benavente-Babace, A., Parent, S., Michie, C., Soucy, N., Steeves, A., Lu, A., Cober, N.D., Courtman, D., Variola, F., Alarcon, E.I., Liang, W., Stewart, D.J., Godin, M., Davis, D.R., Deterministic paracrine repair of injured myocardium using microfluidic-based cocooning of heart explant-derived cells. Biomaterials. doi.org/10.1016/j.biomaterials.2020.120010

Davis, D.R., The cell engraftment hypothesis of cardiac repair. Current Stem Cell Research & Therapy. doi.org/10.2174/1574888x15666200206103005
 
2019 (11)
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Liang, W., Al Qarawi, W., Davis, D.R., Disease modeling and precision medicine using Canadian cardiomyocytes. Canadian Journal of Cardiology. doi.org/10.1016/j.cjca.2019.10.036

Alqarawi, W., Sadek, M., Golian, M., Hibbert, B., Redpath, C., Nair, G., Nery, P., Davis, D.R., Klein, A., Birnie, D.H., Green, M.S. A New electrocardiographic definition of left bundle branch block in patients after transcatheter aortic valve replacement. Journal of Electrocardiography.    doi.org/10.1016/j.jelectrocard.2019.10.005

Mount, S., Kanda, P., Parent, S., Khan, S., Michie, C., Davila, L., Chan, V., Davies, R.A., Haddad, H., Courtman, D., Stewart, D.J., Davis, D.R., Physiologic expansion of human heart-derived cells enhances therapeutic repair of injured myocardium. Stem Cell Research and Therapeutics. doi.org/10.1186/s13287-019-1418-3

Alqarawi, W,, Coppens, J., Aldawood, W., Ramirez, F.D., Redpath, C.J., Nair, G.M., Nery, P.B., Davis, D.R., Abu Shama, R., Aydin, A., Klein, A., Golian, M., Schaller, R.D., Green, M.S., Birnie, D.H., Sadek, M.M., A strategy of lead abandonment in a large cohort of patients with sprint fidelis leads. JACC: Clinical Electrophysiology. http://doi.org/10.1016/j.jacep.2019.07.006

Kanda, P., Parent, S., Davis, D.R., Immortalized factories of therapeutic vesicles. Nature Biomedical Engineering. doi.org/10.1038/s41551-019-0453-9

Tzou, W.S., Hussein, A.A., Madhavan, M., Viswanathan, M.N., Steinberg, B.S., Ceresnak, S.R., Davis, D.R., Park, D.S., Wang, P.J., Kapa, S., Year in review in cardiac electrophysiology. Circulation Arrhythmia and Electrophysiology. doi.org/10.1161/CIRCEP.118.006648

Villanueva, M., Michie, C., Kanaan, G.N., Rafatian, G., Kanda, P., Ye, B., Liang, W., Harper, M-E., Davis, D.R., Glyoxalase 1 prevents chronic hyperglycemia induced heart-explant derived cell dysfunction. Theranostics. http://doi.org/10.7150/thno.36639

Davis, D.R., Paracrine heart repair comes of age. Canadian Journal Cardiology. doi.org/10.1016/j.cjca.2019.07.006

McRae, C., Kapoor, A., Kanda, P., Hibbert, B., Davis, D.R., Systematic review of biological therapies for atrial fibrillation. Heart Rhythm. doi.org/10.1016/j.hrthm.2019.03.021

Liang, W., Gasparyan, L., Al Qarawi, W., Davis D.R., Disease modeling of cardiac arrhythmias using human induced pluripotent stem cells. Expert Opinion Biological Therapies. doi.org/10.1080/14712598.2019.1575359
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Davis, D.R., Heart stem cells in the post-Anversa era. European Heart Journal. doi.org/10.1093/eurheartj/ehz098
 
2018 (7)

Hosoyama, K., Ahumada, M., McTiernan, C., Davis, D.R., Variola, F., Ruel, M., Liang, W., Suuronen, E., Alarcon, E. Nanoengineered electroconductive collagen-based cardiac patch for infarcted myocardium repair. ACS Applied Material Interfaces. doi.org/10.1021/acsami.8b18844

Ramirez, F.D., Sadek, M.M., Boileau, I., Cleland, M., Nery, P.B., Nair, G.M., Redpath, C.J., Green, M.S., Davis, D.R., Charron, K., Henne, J., Zakutney, T., Beanlands, R.S.B., Hibbert, B., Wells, G.A., Birnie, D.H. Evaluation of a novel cardioversion intervention for atrial fibrillation: the Ottawa AF cardioversion protocol. Europace. doi.org/10.1093/europace/euy285

Rafatian, G., Davis, D.R., Heart-Derived Cell Therapy 2.0: Paracrine strategies to increase therapeutic repair of injured myocardium. Stem Cells. doi.org/10.1002/stem.2910

Kapa, S., Davis, D.R., Park, D.S., Steinberg, B.A., Viswanathan, M.N., Tzou, W., Malini, M. Ceresnak, S.R., Wang, P.J., The year in review in cardiac electrophysiology. Circulation Arrhythmia and Electrophysiology. doi.org/10.1161/CIRCEP.118.007142

Alqarawi, W., Birnie, D.H., Spence, S, Ramirez, D., Redpath, C.J., Lemery, R., Nair, G.M., Nery, P.B., Davis, D.R., Green, M., Beauchesne, L., Chan, K., Ascah, K., Burwash, I., Sadek, M.M. Prevalence of left atrial appendage thrombus detected by transoesophageal echocardiography before catheter ablation of atrial fibrillation in patients anticoagulated with non-vitamin K antagonist oral anticoagulants. Europace. doi.org/10.1093/europace/euy129

Vigneault, P., Naud, P., Qi, X., Xiao, J., Villeneuve, L., Davis, D.R., Nattel, S. Calcium-Dependent Potassium Channels Control Proliferation of Cardiac Progenitor Cells and Bone Marrow-derived Mesenchymal Stem Cells. Journal of Physiology. doi.org/10.1113/JP275388

Kanda, P., Alarcon, E.I., Yeuchyk, T., Parent, S., deKemp, R.A., Variola, F., Courtman, D., Stewart, D.J., Davis, D.R., Deterministic micro-encapsulation of human cardiac stem cells in variable composition nanogel cocoons to enhance therapeutic regeneration of injured myocardium. ACS Nano. doi.org/10.1021/acsnano.7b08881
 
2017 (5)

Rafatian, G., Davis, D.R., The frustration and futility of intra-coronary stem cell therapy. Canadian Journal of Cardiology. doi.org/10.1016/j.cjca.2017.09.023

Mayfield, A.E., Dixit, S., Kanda, P., Nantsios, A., Parent, S., Mount, M., Ye, B., Seymour, R., Stewart, D.J., Davis, D.R., Interleukin-6 mediates post-infarct repair by cardiac explant-derived stem cells. Theranostics. doi.org/10.7150/thno.19435

Kanda, P., Davis, D.R., Cellular mechanisms underlying cardiac engraftment of stem cells. Expert Opinion on Biological Therapies. doi.org/10.1080/14712598.2017.1346080

Liang, W., Lu, A., Davis, D.R., Induced pluripotent stem cell-based treatment of acquired heart block. The battle for tomorrow has begun! Circulation Arrhythmia and Electrophysiology. doi.org/10.1161/CIRCEP.117.005331

Jackson, R., Mount,S., Ye, B., Mayfield, A.E., Chan, V., Boodhwani, M., Davies, R.A., Haddad, H., Davis, D.R., Isolation of human cardiac explant derived stem cells from cryopreserved heart tissue.  PLoS ONE. doi.org/10.1371/journal.pone.0176000
 
2016 (5)

Mayfield, A., Fitzpatrick, M., Dixit, S., Latham, N., Tilokee, E.L., Villanueva, M., Mount, S., Lam, B.K., Ruel, M., Stewart, D.J., Davis, D.R., Patient risk for future cardiac events negatively predicts the regenerative capacity of explant-derived cardiac stem cells. Stem Cell Research and Therapeutics. doi.org/10.1186/s13287-016-0321-4

Essebag, V., Verma, A., Healey, J.S., Krahn, A.D., Kalfon, E., Coutu, B., Ayala-Paredes, F., Tang, A.S.L., Sapp, J., Sturmer, M., Keren, A., Wells, G.A., Birnie, D.H.; BRUISE CONTROL Investigators. Clinically significant pocket hematoma increases long-term risk of device infection. JACC. doi.org/10.1016/j.jacc.2016.01.009

Tilokee, E.L., Latham, N., Jackson, R., Ye, B., Lam, B.K., Ruel, M., Suuronen, E., Stewart, D.J., Davis D.R., Paracrine engineering of human cardiac stem cells to over-express stromal-cell derived factor 1α for enhanced myocardial repair. Stem Cells. doi.org/10.1002/stem.2373

Adler A., Sadek M.M., Chan A.Y., Dell E., Rutberg J., Davis D., Green M.S., Spears D.A., Gollob M.H., Patient outcomes from a specialized inherited arrhythmia clinic. Circulation Arrhythmia and Electrophysiology. doi.org/10.1161/CIRCEP.115.003440

Mount, S., Davis, D.R., Electrical effects of stem cell transplantation for ischaemic cardiomyopathy: Friend or Foe? Journal of Physiology. doi.org/10.1113/JP270540
 
2015 (1)
Jackson, R., Tilokee, E.L., Latham, N., Ye, B., Boodhwani, M., Chan, V., Suuronen, E., Stewart, D.J., Davis, D.R., Paracrine engineering of human cardiac stem cells with insulin-like growth factor-1 attenuates cell death and enhances myocardial repair after intra-myocardial injection. JAHA. doi.org/10.1161/JAHA.115.002104
 
2014 (7)

Molgat, ASD, Tilokee, E.L., Rafatian, G., Vulesevic, B., Ruel, M., Milne, R., Suuronen, E.J., Davis, D.R., Hyperglycemia inhibits cardiac stem cell-mediated cardiac repair and angiogenic capacity. Circulation. doi.org/10.1161/CIRCULATIONAHA.113.007908

Mayfield, A., Tilokee, E.L., Davis D.R., Resident cardiac stem cells and their role in stem cell therapeutics for myocardial repair. Canadian Journal of Cardiology. doi.org/10.1016/j.cjca.2014.03.018

Nery, P.B., Beanlands, R.S., Nair, G.N., Green, M.S., Yang, J., Mc Ardle, B.A., Davis, D.R., Gollob, M.H., Leung, E., Healey, J., Birnie, D.H., Atrioventricular block as the initial manifestation of cardiac sarcoidosis in middle-aged adults. Journal of Cardiac Electrophysiology. doi.org/10.1111/jce.12401

Ahmadi, A., McNeill, B., Vulesevic, B., Kordos, M., Mesana, T., Thorn, S., Renaud, J.M., Manthorp, E., Kuraitis, D., Toeg, H., Padavan, D.T., Mesana, T.G., Davis, D.R., Beanlands, R.S., DaSilva, J.N., deKemp, R.A., Ruel, M., Suuronen, E.J., The role of integrin α2 in cell and matrix therapy that improves perfusion, viability and function of infarcted myocardium. Biomaterials. doi.org/10.1016/j.biomaterials.2014.02.028

Yilbas, A.E., Hamilton, A., Wang, Y., Mach, H., Lacroix, N., Davis, D.R., Chen, J., Li, Q., Activation of GATA4 gene expression at the early stage of cardiac specification. Frontiers in Chemistry. doi.org/10.3389/fchem.2014.00012

Mayfield, A., Tilokee, E.L., McNeil, B., Lam, B.K., Ruel, M., Suuronen, E.J., Courtman, D.W., Stewart, D.J., Davis, D.R., The effect of encapsulation of cardiac stem cells within matrix-enriched hydrogel capsules on cell survival, post-ischemic cell retention and cardiac function. Biomaterials. doi.org/10.1016/j.biomaterials.2013.09.085
 
2013 (4)

Latham, N., Ye, B., Jackson, R., Lam, B., Kuriatis, D., Ruel, M., Suuronen, E.J., Stewart, D.J., Davis, D.R., Human blood and cardiac stem cells synergize to enhance cardiac repair when co-transplanted into ischemic myocardium. Circulation. doi.org/10.1161/CIRCULATIONAHA.112.000374

Birnie DH, Healey JS, Wells GA, Verma A, Tang AS, Krahn AD, Simpson CS, Ayala-Paredes F, Coutu B, Leiria TL, Essebag V; BRUISE CONTROL Investigators. Pacemaker or defibrillator surgery without interruption of anticoagulation. NEJM. doi.org/10.1056/NEJMoa1302946

Tilokee, E., Davis, D.R., Circulating progenitor cells as a heart failure biomarker: Does a failing marrow predict a failing heart? Canadian Journal of Cardiology. doi.org/10.1016/j.cjca.2012.09.011

White, A.J., Matsushita, S., Chakravarty, T., Czer, L.S., Burton, K., Scwartz, E.R., Davis, D.R., Simsir, S., Reinsmoen, N.L., Forrester, J.S., Marbán, E., Makkar, R., Intrinsic cardiac origin of human cardiosphere-derived cells. European Heart Journal. doi.org/10.1093/eurheartj/ehr172
 
2012 (5)

Davis, D.R., Stewart, D.J., Selectins for cardiosphere culture- The ‘Es’ have it! Molecular Therapy. doi.org/10.1038/mt.2012.120

Barth A.S., Zhang Y., Li T-S, Smith R.R., Chimenti I., Terrovitis J., Davis D.R., Kizana E., Ho A.S., O'Rourke B., Wolff A.C., Gerstenblith G., Marbán E., Functional impairment of human resident cardiac stem cells contributes to trastuzumab cardiotoxicity. Stem Cells Translational Medicine. doi.org/10.5966/sctm.2011-0016

Al Habashi, Y., Davis D.R. Superior Vena Cava Obstruction due to Pacemaker Leads. Europace. doi.org/10.1093/europace/eus029

Lortie M. DaSilva J.N., Kenk M., Thorn S., Davis D.R., Birnie, D.H., Beanlands R.S., deKemp, R.A. Analysis of (R)- and (S)-[11C]rolipram kinetics in canine myocardium for the evaluation of phosphodiesterase-4 with PET.  Molecular Imaging Biology. doi.org/10.1007/s11307-011-0482-6

Al Habashi, Y., Kass, M., Green M.S., Davis D.R., Posterior His location in structural normal hearts. Canadian Journal of Cardiology. doi.org/10.1016/j.cjca.2010.12.005
 
2011 (1)

Davis, D.R., Stewart, D.J. Autologous stem cells for myocardial repair.  Expert Opinion in Biological Therapies. doi.org/10.1517/14712598.2011.556615
 
2010 (5)

Li, T., Lee, S., Matsushita S., Davis D.R., Zhang, Y., Ruckdeschel Smith, R., Burton K., Marbán, E., Cardiospheres recapitulate a niche-like microenvironment rich in stemness and cell-matrix interactions, rationalizing their enhanced functional potency for myocardial repair. Stem Cells. doi.org/10.1002/stem.532

Jiang, D., Jones, P., Davis, D.R., Gow, R., Green, M.S., Birnie, D.H., Chen, S.R.W. and Gollob, M.H. Identification and characterization of a novel cardiac ryanodine receptor mutation linked to catecholaminergic polymorphic ventricular tachycardia, Channels. doi.org/10.4161/chan.4.4.12666

Hibbert B., Hibbert R., Lim T.W., Green M.S., Gollob M.H., Davis D.R., Ventricular tachycardia following tube thoracotomy. Europace. doi.org/10.1093/europace/euq172

Cheng K, Li TS, Malliaras K, Davis D, Zhang Y, Marbán E. Magnetic targeting enhances engraftment and functional benefit of iron-labeled cardiosphere-derived cells in myocardial infarction. Circulation Research. doi.org/10.1161/CIRCRESAHA.109.212589

Davis, D.R., Kizana, E., Terrovitis, I., Barth, A.S., Smith, R., Miake, J. and Marbán, E., Isolation and expansion of functionally-competent cardiac progenitor cells directly from heart biopsies. Journal of Cellular and Molecular Cardiology. doi.org/10.1016/j.yjmcc.2010.02.019

Davis, D.R., Smith, R., and Marbán, E., Human Cardiospheres are a Source of Stem Cells with Cardiomyogenic Potential. Stem Cells. doi.org/10.1002/stem.413
 
2009 (1)

Davis, D.R., Zhang, Y., Smith, R.R., Cheng, K., Terrovitis, J., Li, T., Malliaras K., White, A., Marbán, E., Validation of the cardiosphere method to culture cardiac progenitor cells from myocardial tissue.  PLoS ONE. doi.org/10.1371/journal.pone.0007195