Featured Research
Our current research program focuses on understanding and modifying the inflammatory and fibrotic atrial substrate that permits atrial fibrillation to develop and persist.
Targeted delivery of clinical-grade human cardiac extracellular vesicles prevented spontaneous postoperative atrial fibrillation and attenuated inflammatory and fibrotic atrial remodeling in a clinically relevant large-animal model.
Read the paper →Human atrial models demonstrate suppression of NLRP3-associated inflammatory and profibrotic signaling, connecting the therapeutic phenotype observed in vivo with human atrial biology.
Read the paper →Atrial Fibrillation & Extracellular Vesicles
These studies trace the program from proof-of-concept through mechanism, comparison with conventional anti-inflammatory therapy, human atrial biology and large-animal translation.
Cardiac Sarcoidosis
Our cardiac sarcoidosis program develops experimental systems that reproduce granulomatous myocardial inflammation, conduction abnormalities, fibrosis and progressive ventricular dysfunction.
Clinical Electrophysiology
Independent validation of the PADIT risk score across cardiac implantable electronic device procedures, including assessment of its performance for pocket and systemic device infections.
Read the paper →A randomized clinical trial examining whether iodine-impregnated adhesive drapes reduce pocket contamination and subsequent infection during repeat cardiac device procedures.
Read the paper →Clinical electrophysiology research examining the extent of substrate modification required during ablation of ischemic ventricular tachycardia.
Read the paper →Prospective evaluation of a standardized repeat-AF ablation strategy incorporating pulmonary vein re-isolation, atrial substrate assessment, non-PV triggers and associated arrhythmias.
Read the paper →Translational Cardiovascular Biology
Earlier work in cardiac regeneration, paracrine signaling and bioengineering established many of the concepts that ultimately led the laboratory toward extracellular vesicles and biological therapy for arrhythmias.
